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发表于

Article title

TOM20-driven E3 ligase recruitment regulates mitochondrial dynamics through PLD6

TOM20 drives FEM1B anchoring mitochondria to recruit PLD6 for mitochondria fusion

Journal

Nature Chemical Biology

Tags

CRLs E3 ligase family; mitochondria dynamics

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Article title

Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance

LSD1 inhibitors utilize Grob fragmentation to exhibit different mechanism of action

Journal

Nature Communications

Tags

Inhibitor mode of action; LSD1 inhibitor; covalent drug

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Article title

A PARP2 active site helix melts to permit DNA damage-induced enzymatic activation

PARP2 utilizes an active site helix to permit DNA-induced activation

Journal

Molecular Cell

Tags

ADP-ribosylation; Allosteric activation; HDX-MS

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Article title

Bidirectional histone monoaminylation dynamics regulate neural rhythmicity

Histone monoaminylation shows dynamic and regulates neural rhythmicity

Journal

Nature

Tags

Histone PTMs; Metabolic PTMs; Genetics

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Article title

Human HDAC6 senses valine abundancy to regulate DNA damage

HDAC is a sensor of valine leading to DNA damage and potent cancer treatment

Journal

Nature

Tags

Small molecule metabolites; DNA damage; Novel cellular pathways

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Article title

Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch

Discover liver disease-targeting small molecule without itch adverse effect

Journal

Cell

Tags

Cryo-EM structure, Drug rational design

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Article title

Targeting cancer with small-molecule pan-KRAS degraders

Targeting cancer with pan-KRAS PROTAC molecule

Journal

Science

Tags

PROTAC, Drug screening

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