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发表于

Article title

NASP modulates histone turnover to drive PARP inhibitor resistance

NASP and PARP1-involving histone H3/H4 cycle in PARPi resistant cells
NASP and PARP1-involving histone H3/H4 cycle in PARPi resistant cells

Journal

Nature

Tags

PARP1; PARP inhibitor, genetics, drug resistance

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Article title

Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation

Schematic illustration of ZUD-based detection approach for cellular ADPr-ubiquitination substrates
Schematic illustration of ZUD-based detection approach for cellular ADPr-ubiquitination substrates

Journal

Nature Chemical Biology

Tags

PARP1; ADPr-ubiquitination; Mass spectrometry; PTMs proteomics

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Article title

Isoform-specific function of NSD3 in DNA replication stress confers resistance to PARP inhibitors in prostate cancer

NSD3S in DNA replication stress determines the resistance to PARPi in prostate cancer
NSD3S in DNA replication stress determines the resistance to PARPi in prostate cancer

Journal

Molecular Cell

Tags

PARP inhibitors; Drug resistance; Prostate cancer

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Article title

BRAF oncogenic mutants evade autoinhibition through a common mechanism

BRAF oncogenic mutants evade autoinhibition through a common mechanism
BRAF oncogenic mutants use common mechanism to evade BRAF autoinhibition

Journal

Science

Tags

BRAF kinase; RAS-ERK pathway; Structural biology; Oncogenic mutation

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Article title

TOM20-driven E3 ligase recruitment regulates mitochondrial dynamics through PLD6

TOM20 drives FEM1B anchoring mitochondria to recruit PLD6 for mitochondria fusion
TOM20 drives FEM1B anchoring mitochondria to recruit PLD6 for mitochondria fusion

Journal

Nature Chemical Biology

Tags

CRLs E3 ligase family; mitochondria dynamics

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Article title

Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance

LSD1 inhibitors utilize Grob fragmentation to exhibit different mechanism of action
LSD1 inhibitors utilize Grob fragmentation to exhibit different mechanism of action

Journal

Nature Communications

Tags

Inhibitor mode of action; LSD1 inhibitor; covalent drug

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