-徐-

坐看日月行, 细数千帆过

发表于 更新于

Article title

Isoform-specific function of NSD3 in DNA replication stress confers resistance to PARP inhibitors in prostate cancer

NSD3S in DNA replication stress determines the resistance to PARPi in prostate cancer
NSD3S in DNA replication stress determines the resistance to PARPi in prostate cancer

Journal

Molecular Cell

Tags

PARP inhibitors; Drug resistance; Prostate cancer

阅读全文 »

发表于 更新于

Article title

BRAF oncogenic mutants evade autoinhibition through a common mechanism

BRAF oncogenic mutants evade autoinhibition through a common mechanism
BRAF oncogenic mutants use common mechanism to evade BRAF autoinhibition

Journal

Science

Tags

BRAF kinase; RAS-ERK pathway; Structural biology; Oncogenic mutation

阅读全文 »

发表于 更新于

Article title

TOM20-driven E3 ligase recruitment regulates mitochondrial dynamics through PLD6

TOM20 drives FEM1B anchoring mitochondria to recruit PLD6 for mitochondria fusion
TOM20 drives FEM1B anchoring mitochondria to recruit PLD6 for mitochondria fusion

Journal

Nature Chemical Biology

Tags

CRLs E3 ligase family; mitochondria dynamics

阅读全文 »

发表于 更新于

Article title

Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance

LSD1 inhibitors utilize Grob fragmentation to exhibit different mechanism of action
LSD1 inhibitors utilize Grob fragmentation to exhibit different mechanism of action

Journal

Nature Communications

Tags

Inhibitor mode of action; LSD1 inhibitor; covalent drug

阅读全文 »

发表于 更新于

Article title

A PARP2 active site helix melts to permit DNA damage-induced enzymatic activation

PARP2 utilizes an active site helix to permit DNA-induced activation
PARP2 utilizes an active site helix to permit DNA-induced activation

Journal

Molecular Cell

Tags

ADP-ribosylation; Allosteric activation; HDX-MS

阅读全文 »

发表于 更新于

Article title

Bidirectional histone monoaminylation dynamics regulate neural rhythmicity

Histone monoaminylation shows dynamic and regulates neural rhythmicity
Histone monoaminylation shows dynamic and regulates neural rhythmicity

Journal

Nature

Tags

Histone PTMs; Metabolic PTMs; Genetics

阅读全文 »

发表于 更新于

Article title

Human HDAC6 senses valine abundancy to regulate DNA damage

Human HDAC6 senses valine abundancy to regulate DNA damage
HDAC is a sensor of valine leading to DNA damage and potent cancer treatment

Journal

Nature

Tags

Small molecule metabolites; DNA damage; Novel cellular pathways

阅读全文 »