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坐看日月行, 细数千帆过

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Article title

High-throughput ligand diversification to discover chemical inducers of proximity

High-throughput ligand diversification to discover chemical inducers of proximity
Ligand diversification to discover CIPs

Journal

Nature Chemical Biology

Tags

Molecular glue; SuFEX; drug screening

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第一间黑龙极难，基本只有绽放能打

第二间月感电，有人机就好说

第三间龙王轻松打，但我无龙王，用丝柯克也能较为轻松打过去

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Article title

Antibody-lectin chimeras for glyco-immune checkpoint blockade

Mechanism of antibody-lectin chimeras for glyco-immune checkpoint blockade
Antibody-lectin chimeras for glyco-immune checkpoint blockade

Journal

Nature Biotechnology

Tags

Glycan; Checkpoint blockade therapy; Engineered antibody

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Article title

A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement

Chemical agonist and PI4P concertly activate STING and downstream pathways
Chemical agonist and PI4P concertly activate STING and downstream pathways

Journal

Immunity

Authors

Conggang Zhang (Tsinghua University)

Tags

cGAS-STING; PI4P; Molecular glue

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暝视龙难度高，跳楼机难度较高，深罪浸礼者最简单。

N5低金，超载感觉是版本答案

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Article title

Development of a targeted BioPROTAC degrader selective for misfolded SOD1

Development of BioPROTAC for SOD1 degradation
Development of BioPROTAC for SOD1 degradation

Journal

Nature communications

Tags

Gene therapy; BioPROTAC; Degenerative disease

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Article title

Lysine-specific histone demethylase complex restricts Epstein–Barr virus lytic reactivation

CRISPR screening for EBV reactivation-related genes
CRISPR screening for EBV reactivation-related genes

Journal

Nature Microbiology

Tags

Reverse genetics; Histone demethylase

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整体还是比较难的，第二间和第一间，总有一间需要月反应角色。第三间比较需要仆人，但对配对要求不高，低金的超载也可以打。

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