Article title

A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement

Journal

Immunity

Authors

Conggang Zhang (Tsinghua University)

Tags

cGAS-STING; PI4P; Molecular glue

暝视龙难度高，跳楼机难度较高，深罪浸礼者最简单。

N5低金，超载感觉是版本答案

Article title

Development of a targeted BioPROTAC degrader selective for misfolded SOD1

Journal

Nature communications

Tags

Gene therapy; BioPROTAC; Degenerative disease

Article title

Lysine-specific histone demethylase complex restricts Epstein–Barr virus lytic reactivation

Journal

Nature Microbiology

Tags

Reverse genetics; Histone demethylase

整体还是比较难的，第二间和第一间，总有一间需要月反应角色。第三间比较需要仆人，但对配对要求不高，低金的超载也可以打。

Article title

Diffusing protein binders to intrinsically disordered proteins

Journal

Nature

Tags

Protein design; RFdiffusion; Protein tool development

第二间极其需要菈乌玛；第三间除了牛牛以外的0+0雷C，力度已经不太够了。第一间较为好打。

Article title

NASP modulates histone turnover to drive PARP inhibitor resistance

Journal

Nature

Tags

PARP1; PARP inhibitor, genetics, drug resistance

整体难度偏难，5.0之前的队伍相当难打

最难的是次数盾，是真的太粪了

Article title

Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation

Journal

Nature Chemical Biology

Tags

PARP1; ADPr-ubiquitination; Mass spectrometry; PTMs proteomics