Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch

Cryo-EM structure of DNMT3A1 UDR domain with H2A119Ub NCP

Journal

Science Advances

Tags

DNA methylation; Ubiquitinated nucleosome complex; Genetics

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Article Summary 2024-08-27

发表于 2024-08-27 更新于 2026-07-11

Article title

Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin

Cryo-EM structure of PARP2/HPF1 bound to nucleosome

Journal

Nature

Tags

Nucleosome; PARP1; Cryo-EM structure

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Article Summary 2024-08-23

发表于 2024-08-23 更新于 2026-07-11

Article title

Structure and repair of replication-coupled DNA breaks

Replication-associated DSBs are processed differently from canonical one

Journal

Science

Tags

DNA replication; Next generation sequencing

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GI screenshot 8/21/24

发表于 2024-08-22 更新于 2026-07-21

4 GI screenshots taken in last year.

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Upload images to hexo-based github.io portfolio

发表于 2024-08-21 更新于 2026-06-09

Aim

To upload images to my portfolio which is constructed by hexo-based github.io.

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Article Summary 2024-08-21

发表于 2024-08-21 更新于 2026-07-11

Article title

A ubiquitin-specific, proximity-based labeling approach for the identification of ubiquitin ligase substrates

Journal

Science advances

Tags

E3 ligase; Promixity labeling

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