Article title

A PARP2 active site helix melts to permit DNA damage-induced enzymatic activation

Journal

Molecular Cell

Tags

ADP-ribosylation; Allosteric activation; HDX-MS

Article title

Bidirectional histone monoaminylation dynamics regulate neural rhythmicity

Journal

Nature

Tags

Histone PTMs; Metabolic PTMs; Genetics

Article title

Human HDAC6 senses valine abundancy to regulate DNA damage

Journal

Nature

Tags

Small molecule metabolites; DNA damage; Novel cellular pathways

Article title

Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch

Journal

Cell

Tags

Cryo-EM structure, Drug rational design

Article title

Targeting cancer with small-molecule pan-KRAS degraders

Journal

Science

Tags

PROTAC, Drug screening

目标

使用Origin和Adobe Illustrator将原始的交联质谱数据转化为圆环形交联质谱图

不可放下骄傲之心

Article title

Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch

Journal

Science Advances

Tags

DNA methylation; Ubiquitinated nucleosome complex; Genetics

Article title

Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin

Journal

Nature

Tags

Nucleosome; PARP1; Cryo-EM structure

Article title

Structure and repair of replication-coupled DNA breaks

Journal

Science

Tags

DNA replication; Next generation sequencing