发表文章

1. Advances on structural mechanisms of ubiquitinated nucleosome complexes.
   Ziyu Xu, Huasong Ai, Maoshen Sun, Jiakun Tian, Lei Liu*.
   Sci. Sin. Chim., 2020, 50, 415–436.
   文章链接

2. Unique gluing effect of ASXL1 K351 monoubiquitination stimulates the PR-DUB activity.
   Tianyi Zhang, Jiqing Zheng, Zebing Tong, Zhiheng Deng, Zaozhen He, Xiangwei Wu, Miao Wang, Yunxiang Du, Ziyu Xu, Shixian Tao, Shizhang Wan, Xiaolin Tian, Haiteng Deng, Man Pan*, Huasong Ai*, Lei Liu*.
   Nat. Chem. Biol., 2026.
   DOI

3. Structural basis for E4 enzyme Ufd2-catalyzed K48/K29 branched ubiquitin chains.
   Zebin Tong, Xiangwei Wu, Hongyi Cai, Shidian Wu, Tianyi Zhang, Zhiheng Deng, Ziyu Xu, Rujing Yuan, Huasong Ai*, Lei Liu*, Man Pan*.
   Nat. Chem. Biol., 2026, 22, 239–248.
   DOI

4. RAD18-catalysed formation of ubiquitination intermediate mimic of proliferating cell nuclear antigen PCNA.
   Liying Zhang, Zhiheng Deng, Yunxiang Du, Ziyu Xu, Tianyi Zhang, Zebin Tong, Huasong Ai, Lu-Jun Liang*, Lei Liu*.
   Bioorg. Med. Chem., 2025, 117, 118016.
   DOI

5. Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes.
   Zebin Tong, Huasong Ai*, Ziyu Xu, Kezhang He, Guo-Chao Chu, Qiang Shi, Zhiheng Deng, Qiaomei Xue, Maoshen Sun, Yunxiang Du, Lujun Liang, Jia-Bin Li, Man Pan*, Lei Liu*.
   Nat. Struct. Mol. Biol., 2024, 31, 300–310.
   DOI

6. Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A.
   Zhiheng Deng, Huasong Ai, Maoshen Sun, Zebin Tong, Yunxiang Du, Qian Qu, Liying Zhang, Ziyu Xu, Shixian Tao, Qiang Shi, Jia-Bin Li, Man Pan, Lei Liu*.
   Mol. Cell, 2023, 83, 3080–3094.
   DOI

7. Chemical mechanisms of nucleosomal histone ubiquitination by RING-type E3 enzymes.
   Qiang Shi, Zebin Tong, Zhiheng Deng, Ziyu Xu, Huasong Ai, Yang Liu, Lei Liu*.
   Sci. Sin. Chim., 2023, 53, 1455–1471.
   DOI

8. Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination.
   Huasong Ai, Zebin Tong, Zhiheng Deng, Jiakun Tian, Liying Zhang, Maoshen Sun, Yunxiang Du, Ziyu Xu, Qiang Shi, Lujun Liang, Qingyun Zheng, Jia-Bin Li, Man Pan*, Lei Liu*.
   Chem, 2023, 9, 1221–1240.
   DOI

9. Chemical synthesis of post-translationally modified H2AX reveals redundancy in interplay between histone phosphorylation, ubiquitination, and methylation on the binding of 53BP1 with nucleosomes.
   Huasong Ai, Guo-Chao Chu, Qingyue Gong, Ze-Bin Tong, Zhiheng Deng, Xin Liu, Fan Yang, Ziyu Xu, Jia-Bin Li*, Changlin Tian*, Lei Liu*.
   J. Am. Chem. Soc., 2022, 144, 18329–18337.
   DOI